Serum albumin and health in older people: Review and meta analysis

被引：389

作者：

Cabrerizo, Sonia ^{[1
]}

Cuadras, Daniel ^{[2
]}

Gomnez-Busto, Fernando ^{[3
]}

Artaza-Artabe, Inaki ^{[4
]}

Martin Ciancas, Fernando ^{[5
]}

Malafarina, Vincenzo ^{[5
]}

机构：

[1] Grp Viamed, Clin Manzanos, Nutr Serv, Lardero 26140, Spain

[2] Fdn St Joan de Deu, Serv Assessorament Metodol & Estadist RecercaUnit, St Boi De Llobregat, Barcelona, Spain

[3] Residencia San Prudencia, Dept Geriatr, Vitoria 01002, Spain

[4] Grp Igurco, Orue Ctr Socio Sanitario, Dept Geriatr, Amorebieta 48340, Spain

[5] Grp Viamed, Clin Manzanos, Dept Geriatr, Lardero 26140, Spain

来源：

MATURITAS | 2015年 / 81卷 / 01期

关键词：

Hypoalbuminemia; Undemutrition; Ageing; Protein energy malnutrition; Nutritional screening; Body composition; HIP FRACTURE PATIENTS; PROTEIN-ENERGY MALNUTRITION; SHORT-TERM MORTALITY; NUTRITIONAL-STATUS; ELDERLY-PATIENTS; BODY-COMPOSITION; HOSPITALIZED-PATIENTS; FUNCTIONAL STATUS; PROGNOSTIC VALUE; MUSCLE STRENGTH;

D O I：

10.1016/j.maturitas.2015.02.009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Albumin is the most abundant plasmatic protein. It is only produced by the liver and the full extent of its metabolic functions is not known in detail. One of the main roles assigned to albumin is as an indicator of malnutrition. There are many factors, in addition to nutrition, that influence levels of albumin in plasma. The main aim of this review is to assess the clinical significance of albumin in elderly people in the community, in hospital and in care homes. Following the review, it can be stated that age is not a cause of hypoalbuminemia. Albumin is a good marker of nutritional status in clinically stable people. Significant loss of muscle mass has been observed in elderly people with low albumin levels. Hypoalbuminemia is a mortality prognostic factor in elderly people, whether they live in the community or they are in hospital or institutionalized. Low levels of albumin are associated to worse recovery following acute pathologies. Inflammatory state and, particularly, high concentrations of IL-6 and TNF-alpha, are two of the main influencing factors of hypoalbuminemia. In elderly patients with a hip fracture, albumin levels below 38 g/L are associated to a higher risk of post-surgery complications, especially infections. Further research is needed on the impact of nutritional intervention upon albumin levels and on the outcomes in elderly people in the community, in hospital and in care. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：17 / 27

页数：11

共 76 条

[21] Malnutrition in hospitalized elderly patients: when does it matter? [J].

Gariballa, SE .

CLINICAL NUTRITION, 2001, 20 (06) :487-491

[22] Relationship between serum albumin level and aging in community-dwelling self-supported elderly population [J].

Gomi, Ikuko ;

Fukushima, Hideki ;

Shiraki, Makoto ;

Miwa, Yoshiyuki ;

Ando, Takashi ;

Takai, Kuniyuki ;

Moriwaki, Hisataka .

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 2007, 53 (01) :37-42

[23] In-Hospital Mortality in Patients Older Than 60 Years With Very Low Albumin Levels [J].

Hannan, Jodi L. ;

Radwany, Steven M. ;

Albanese, Terry .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2012, 43 (03) :631-637

[24] Metabolism and catabolism in hip fracture patients -: Nutritional and anabolic intervention -: a review [J].

Hedstrom, Margareta ;

Ljungqvist, Olle ;

Cederholm, Tommy .

ACTA ORTHOPAEDICA, 2006, 77 (05) :741-747

[25]

Iwata M, 2006, AGING CLIN EXP RES, V18, P307

[26] USE OF SERUM-ALBUMIN FOR DIAGNOSING NUTRITIONAL-STATUS IN THE ELDERLY - IS IT WORTH IT [J].

KELLER, HH .

CLINICAL BIOCHEMISTRY, 1993, 26 (06) :435-437

[27] DISCRIMINANT BIOCHEMICAL MARKERS FOR EVALUATING THE NUTRITIONAL-STATUS OF ELDERLY PATIENTS IN LONG-TERM CARE [J].

KERGOAT, MJ ;

LECLERC, BS ;

PETITCLERC, C ;

IMBACH, A .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1987, 46 (05) :849-861

[28]

Kitamura Kaori, 2012, Environmental Health and Preventive Medicine, V17, P164, DOI 10.1007/s12199-011-0233-y

[29] Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care [J].

Kitamura, Kaori ;

Nakamura, Kazutoshi ;

Nishiwaki, Tomoko ;

Ueno, Kimiko ;

Hasegawa, Mariko .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 221 (01) :29-34

[30] ALBUMIN LEVELS AS A PREDICTOR OF MORTALITY IN THE HEALTHY ELDERLY [J].

KLONOFFCOHEN, H ;

BARRETTCONNOR, EL ;

EDELSTEIN, SL .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1992, 45 (03) :207-212

← 1 2 3 4 5 6 7 8 →