The hypothalamic-pituitary-adrenal axis and viral infection

被引：77

作者：

Bailey, M

Engler, H

Hunzeker, J

Sheridan, JF

机构：

[1] Ohio State Univ, Coll Dent, Sect Oral Biol, Ctr Hlth Sci, Columbus, OH 43218 USA

[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Coll Med & Publ Hlth, Ctr Hlth Sci, Columbus, OH USA

[3] Ohio State Univ, Inst Behav Med Res, Ctr Hlth Sci, Columbus, OH USA

来源：

VIRAL IMMUNOLOGY | 2003年 / 16卷 / 02期

关键词：

D O I：

10.1089/088282403322017884

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The hypothalamic-pituitary-adrenal (HPA) axis plays an important immunomodulatory role during viral infection. Activation of the HPA axis ultimately leads to elevated plasma levels of glucocorticoid (GC) hormones with the ability to mediate adaptive behavioral, metabolic, cardiovascular and immune system effects. In this review, we focus on the modulation of anti-viral immunity and viral pathogenesis by the HPA axis.

引用

页码：141 / 157

页数：17

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