Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia

被引:20
作者
Zhang, HL
Huang, ZH
Zhu, Y
Liang, ZQ
Han, R
Wang, XX
Chase, TN
Qin, ZH
机构
[1] Soochow Univ, Sch Med, Dept Pharmacol, Suzhou 215007, Peoples R China
[2] NINDS, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA
基金
中国国家自然科学基金;
关键词
prostaglandin A(1); middle cerebral artery occlusion; ischemia; reperfusion; neuroprotection;
D O I
10.1016/j.brainres.2005.01.046
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study evaluated the neuroprotective potential of prostaglandin A(1) (PGA(1)) in rodent models of focal cerebral ischemia. PGA(1) 33 nmol reduced infarction volume by about 43% (P < 0.05) when administered intracerebroventricularly before and after transient ischemia in mice. PGA(1) 16.5-66 nmol diminished infarction volume by 18% to 27% (P < 0.01) when administered immediately following permanent ischemia in rats. PGA(1) treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA(1) protects neurons from ischemic injury. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:203 / 206
页数:4
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