The GRAIDS Trial: The development and evaluation of computer decision support for cancer genetic risk assessment in primary care

被引：27

作者：

Emery, J ^{[1
]}

机构：

[1] Univ Western Australia, Sch Primary Aboriginal & Rural Hlth Care, Perth, WA 6010, Australia

来源：

ANNALS OF HUMAN BIOLOGY | 2005年 / 32卷 / 02期

关键词：

primary care computer decision support; cancer genetics; complex interventions;

D O I：

10.1080/03014460500074921

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

The development and evaluation of computer decision support for the assessment of cancer genetic risk in primary care is reported with two series of studies described: the RAGs ( Risk Assessment in Genetics) studies and the GRAIDS ( Genetic Risk Assessment in an Intranet and Decision Support) Trial. In the GRAIDS Trial, 45 general practices in Eastern England have been recruited and randomised. Comparison practices attend an educational session and receive clinical guidelines about familial breast and colorectal cancer. In the intervention practices a lead clinician is trained in cancer genetics and use of the GRAIDS software. The GRAIDS software is a simple pedigree-drawing program that implements clinical guidelines for familial breast and colorectal cancer and presents individualised information about breast cancer risk in a range of formats. Outcome measures of the trial include: frequency of software use, practitioners' attitudes towards the software, total number of referrals to secondary care about familial cancer and the proportion that meet regional referral criteria, and a patient-centred measure of informed decision making. The family history will become an increasingly important tool in primary care to assess genetic risk. This research evaluates an approach to support high-quality advice about cancer genetics in primary care which could be applied more broadly as our understanding of complex disease genetics increases.

引用

页码：218 / 227

页数：10

共 32 条

[21] Genetics education for primary care providers in community health settings [J].

Kolb, SE ;

Aguilar, MC ;

Dinenberg, M ;

Kaye, CI .

JOURNAL OF COMMUNITY HEALTH, 1999, 24 (01) :45-59

[22]

Lipkus I M, 1999, J Natl Cancer Inst Monogr, P149

[23]

Marteau T M, 2001, Health Expect, V4, P99, DOI 10.1046/j.1369-6513.2001.00140.x

[24] Evaluation of computer based clinical decision support system and risk chart for management of hypertension in primary care: randomised controlled trial [J].

Montgomery, AA ;

Fahey, T ;

Peters, TJ ;

MacIntosh, C ;

Sharp, DJ .

BRITISH MEDICAL JOURNAL, 2000, 320 (7236) :686-690

[25] Reconsidering the family history in primary care [J].

Rich, EC ;

Burke, W ;

Heaton, CJ ;

Haga, S ;

Pinsky, L ;

Short, MP ;

Acheson, L .

JOURNAL OF GENERAL INTERNAL MEDICINE, 2004, 19 (03) :273-280

[26]

Rimer B K, 1999, J Natl Cancer Inst Monogr, P140

[27] Barriers to the provision of genetic services by primary care physicians: A systematic review of the literature [J].

Suther, S ;

Goodson, P .

GENETICS IN MEDICINE, 2003, 5 (02) :70-76

[28] Computer support for determining drug dose: systematic review and meta-analysis [J].

Walton, R ;

Dovey, S ;

Harvey, E ;

Freemantle, N .

BRITISH MEDICAL JOURNAL, 1999, 318 (7189) :984-990

[29] Education improves general practitioner (GP) management of familial breast/ovarian cancer: findings from a cluster randomised controlled trial [J].

Watson, E ;

Clements, A ;

Lucassen, A ;

Yudkin, P ;

Mackay, J ;

Austoker, J .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (10) :779-781

[30]

Worrall G, 1997, CAN MED ASSOC J, V156, P1705

← 1 2 3 4 →