Recent developments on KCNQ potassium channel openers

被引：44

作者：

Wu, YJ

Dworetzky, SI

机构：

[1] Bristol Myers Squibb Co, Dept Neurosci Chem, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Co, Dept Neurosci Biol, Wallingford, CT 06492 USA

[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 04期

关键词：

D O I：

10.2174/0929867053363045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2/KCNQ3 proteins, and the KCNQ5/KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents. Several lines of evidence are emerging demonstrating the importance of these channels in regulating neuronal excitability; for example, determination of the excitability threshold, firing properties, and responsiveness of neurons to synaptic inputs. Recent studies have shown that KCNQ openers have potential for the treatment of several CNS disorders characterized by neuronal hyperexcitability, such as migraine, epilepsy and neuropathic pain. This article reviews the recent developments of KCNQ potassium channel openers.

引用

页码：453 / 460

页数：8

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[1] Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices [J].