Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin

被引：61

作者：

Nguyen, VQ

Caprioli, RM

Cover, TL ^{[1
]}

机构：

[1] Vanderbilt Univ, Div Infect Dis, Med Ctr N A3310, Sch Med,Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Mass Spectrometry Res Ctr, Sch Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Microbiol & Immunol, Sch Med, Nashville, TN 37232 USA

[4] Vet Affairs Med Ctr, Nashville, TN 37212 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期

关键词：

D O I：

10.1128/IAI.69.1.543-546.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The vacA gene of Helicobacter pylori strain 60190 encodes a 1,287-amino-acid protoxin, which undergoes cleavage of a 33-amino-acid amino-terminal signal sequence and carboxy-terminal proteolytic processing to yield a mature secreted toxin. Several features of VacA suggest that it belongs to the autotransporter family of gram-negative bacterial secreted proteins. Based on matrix-assisted laser desorption ionization-time of flight mass spectrometric analysis, we calculate that the mature toxin has a mass of 88.2 +/- 0.2 kDa and consists of approximately 821 amino acids.

引用

页码：543 / 546

页数：4

共 17 条

[1] The vacuolating cytotoxin of Helicobacter pylori [J].