The neuroendocrinology of obesity

被引:29
作者
Lustig, RH [1 ]
机构
[1] Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0889-8529(05)70211-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The regulation of energy balance occurs in the hypothalamus. There, afferent hormonal and neural signals are integrated to influence the efferents signal of caloric intake and energy expenditure. Defects in this complex neuroendocrine negative feedback loop give rise to various known hormonal and genetic obesity syndromes, and provide insight into therapeutic strategies for obesity management.
引用
收藏
页码:765 / +
页数:22
相关论文
共 121 条
  • [71] LIEBOWITZ SF, 1993, PHARM BIOCH BEHAV, V45, P185
  • [72] Towards a molecular understanding of adaptive thermogenesis
    Lowell, BB
    Spiegelman, BM
    [J]. NATURE, 2000, 404 (6778) : 652 - 660
  • [73] Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist
    Lustig, RH
    Rose, SR
    Burghen, GA
    Velasquez-Mieyer, P
    Broome, DC
    Smith, K
    Li, H
    Hudson, MM
    Heideman, RL
    Kun, LE
    [J]. JOURNAL OF PEDIATRICS, 1999, 135 (02) : 162 - 168
  • [74] LUSTIG RH, 2001, 6 LWPES ESPE M
  • [75] LUSTIG RH, UNPUB J CLIN ENDOCRI
  • [76] A longitudinal assessment of hormonal and physical alterations during normal puberty in boys .5. Rising leptin levels may signal the onset of puberty
    Mantzoros, CS
    Flier, JS
    Rogol, AD
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (04) : 1066 - 1070
  • [77] ROLE OF INTRAHYPOTHALAMIC INSULIN IN CIRCADIAN PATTERNS OF FOOD-INTAKE, ACTIVITY, AND BODY-TEMPERATURE
    MCGOWAN, MK
    ANDREWS, KM
    GROSSMAN, SP
    [J]. BEHAVIORAL NEUROSCIENCE, 1992, 106 (02) : 380 - 385
  • [78] Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic β-cells
    Mitra, SW
    Mezey, É
    Hunyady, B
    Chamberlain, L
    Hayes, E
    Foor, F
    Wang, YN
    Schonbrunn, A
    Schaeffer, JM
    [J]. ENDOCRINOLOGY, 1999, 140 (08) : 3790 - 3796
  • [79] MIURA T, 1996, INT J BIOCHROMATO, V2, P67
  • [80] Congenital leptin deficiency is associated with severe early-onset obesity in humans
    Montague, CT
    Farooqi, IS
    Whitehead, JP
    Soos, MA
    Rau, H
    Wareham, NJ
    Sewter, CP
    Digby, JE
    Mohammed, SN
    Hurst, JA
    Cheetham, CH
    Earley, AR
    Barnett, AH
    Prins, JB
    ORahilly, S
    [J]. NATURE, 1997, 387 (6636) : 903 - 908