GATA transcription factors integrate Wnt signalling during heart development

被引：75

作者：

Afouda, Boni A. ^{[1
]}

Martin, Jennifer ^{[1
]}

Liu, Fei ^{[1
]}

Ciau-Uitz, Aldo ^{[2
]}

Patient, Roger ^{[2
]}

Hoppler, Stefan ^{[1
]}

机构：

[1] Univ Aberdeen, Sch Med Sci, Inst Med Sci, Cell & Dev Biol Res Programme, Aberdeen AB25 2ZD, Scotland

[2] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Mol Haematol Unit, Oxford OX3 9DS, England

来源：

DEVELOPMENT | 2008年 / 135卷 / 19期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

cardiomyogenesis; GATA; heart; Wnt; Xenopus;

D O I：

10.1242/dev.026443

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

引用

页码：3185 / 3190

页数：6

共 42 条

[1]

GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression in Xenopus embryos [J].