α-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification

被引:17
作者
Hishikawa, N
Hashizume, Y
Ujihira, N
Okada, Y
Yoshida, M
Sobue, G
机构
[1] Nagoya Univ, Grad Sch Med, Showa Ku, Dept Neurol, Nagoya, Aichi 4668550, Japan
[2] Aichi Med Univ, Dept Neuropathol, Inst Med Sci Aging, Aichi, Japan
[3] Nagoya Daini Red Cross Hosp, Dept Lab & Med, Nagoya, Aichi, Japan
关键词
alpha-synuclein; diffuse neurofibrillary tangle with calcification; Lewy body; neurofibrillary tangle; tau;
D O I
10.1046/j.1365-2990.2003.00470.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
alpha-Synuclein is known to be a major constituent of the Lewy bodies (LBs) in Parkinson's disease (PD) and the neuronal and glial cytoplasmic inclusions (NCIs, GCIs) in multiple system atrophy. alpha-Synuclein-positive inclusions such as LBs, NCIs and GCIs sometimes show colocalization with tau-positive neurofilaments. Studies using alpha-synuclein immunohistochemistry have often found LBs in the amygdala of patients with familial or sporadic Alzheimer's disease (AD), as well as in patients with Down's syndrome and AD. However, no studies have reported alpha-synuclein-positive structures in cases of diffuse neurofibrillary tangles with calcification (DNTC), which is characterized by numerous neurofibrillary tangles (NFTs) throughout the cerebral cortex but few, if any, senile plaques. We investigated the distribution of alpha-synuclein-positive structures in two cases of DNTC: a 65-year-old woman (brain weight, 850 g) and a 75-year-old woman (brain weight, 800 g). In both cases, severe cerebral atrophy predominant in the temporal lobe was noted. Microscopically, alpha-synuclein-positive intracytoplasmic inclusions and neurites were found in the superior temporal lobe (within the temporal pole), amygdala, parahippocampus, entorhinal cortex and insula, the regions most affected by the NFTs. alpha-Synuclein-positive intracytoplasmic inclusions were rare or absent in other regions of the cerebral cortex and brainstem. This distribution pattern differs from that of PD or dementia with LBs. Our findings suggest that the accumulation pattern of alpha-synuclein is a pathological feature of DNTC, and that DNTC is associated with accumulation of both tau and alpha-synuclein.
引用
收藏
页码:280 / 287
页数:8
相关论文
共 34 条
[1]  
ANDO S, 1965, ADV NEUROL SCI, V9, P181
[2]   α-Synuclein-positive structures in cases with sporadic Alzheimer's disease:: morphology and its relationship to tau aggregation [J].
Arai, Y ;
Yamazaki, M ;
Mori, O ;
Muramatsu, H ;
Asano, G ;
Katayama, Y .
BRAIN RESEARCH, 2001, 888 (02) :287-296
[3]   Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies [J].
Arima, K ;
Hirai, S ;
Sunohara, N ;
Aoto, K ;
Izumiyama, Y ;
Uéda, K ;
Ikeda, K ;
Kawai, M .
BRAIN RESEARCH, 1999, 843 (1-2) :53-61
[4]   NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy [J].
Arima, K ;
Uéda, K ;
Sunohara, N ;
Arakawa, K ;
Hirai, S ;
Nakamura, M ;
Tonozuka-Uehara, H ;
Kawai, M .
ACTA NEUROPATHOLOGICA, 1998, 96 (05) :439-444
[5]   NACP/α-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies:: double-immunolabeling fluorescence and electron microscopic studies [J].
Arima, K ;
Mizutani, T ;
Alim, MA ;
Tonozuka-Uehara, H ;
Izumiyama, Y ;
Hirai, S ;
Uéda, K .
ACTA NEUROPATHOLOGICA, 2000, 100 (02) :115-121
[6]   Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies [J].
Arima, K ;
Uéda, K ;
Sunohara, N ;
Hirai, S ;
Izumiyama, Y ;
Tonozuka-Uehara, H ;
Kawai, M .
BRAIN RESEARCH, 1998, 808 (01) :93-100
[7]  
Baba M, 1998, AM J PATHOL, V152, P879
[8]  
BRION JP, 1995, AM J PATHOL, V147, P1465
[9]   Filamentous nerve cell inclusions in neurodegenerative diseases:: tauopathies and α-synucleinopathies [J].
Goedert, M .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1999, 354 (1386) :1101-1118
[10]  
Hamilton RL, 2000, BRAIN PATHOL, V10, P378