NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

被引：222

作者：

Arima, K

Uéda, K

Sunohara, N

Arakawa, K

Hirai, S

Nakamura, M

Tonozuka-Uehara, H

Kawai, M

机构：

[1] Tokyo Inst Psychiat, Dept Ultrastruct & Histochem, Setagaya Ku, Tokyo 1568585, Japan

[2] Tokyo Inst Psychiat, Dept Neurochem, Setagaya Ku, Tokyo 1568585, Japan

[3] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Dept Lab Med, Tokyo 1878551, Japan

[4] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Dept Neurol, Tokyo 1878551, Japan

[5] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Dept Psychiat, Tokyo 1878551, Japan

来源：

ACTA NEUROPATHOLOGICA | 1998年 / 96卷 / 05期

关键词：

NACP; synuclein; multiple system atrophy; neuronal cytoplasmic inclusions; glial cytoplasmic inclusions;

D O I：

10.1007/s004010050917

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA? and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

引用

页码：439 / 444

页数：6

共 16 条

[1] IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF NEURONAL AND OLIGODENDROGLIAL CYTOPLASMIC INCLUSIONS IN MULTIPLE SYSTEM ATROPHY .1. NEURONAL CYTOPLASMIC INCLUSIONS [J].