Introduction to signal transduction - A primer for untangling the web of intracellular messengers

The field of signal transduction developed from our need to understand the specific mechanisms involved in the transmission of extracellular signals to intracellular actions in target cells. As our comprehension of cellular function has grown, it has become clear that the need to understand signal transduction events has invaded all fields of biological science. Many scientists learned about adenylate cyclase and cyclic AMP when they were students but went on to focus on some other aspect of science; now they find the need to apply studies of signal transduction to their own work. However, the field of signal transduction has progressed so rapidly that from starting with a rudimentary knowledge of adenylate cyclase and cyclic AMP to understanding the field and applying the knowledge to one's own work seems insurmountable. The goal of this commentary is to provide a starting point for those who recognize the need to understand the mechanisms of signal transduction but do not know where or how to begin. BIOCHEM PHARMACOL 55;12:1927-1938, 1998. (C) 1998 Elsevier Science Inc.