Nanostructure-Initiator Mass Spectrometry Metabolite Analysis and Imaging

被引：113

作者：

Greving, Matthew P. ^{[1
]}

Patti, Gary J. ^{[2
]}

Siuzdak, Gary ^{[3
]}

机构：

[1] Scripps Res Inst, Gary Siuzdaks Lab, Dept Chem, Ctr Metabol & Mass Spectrometry, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Lab Gary Siuzdak, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Ctr Metabol, La Jolla, CA 92037 USA

来源：

ANALYTICAL CHEMISTRY | 2011年 / 83卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DESORPTION ELECTROSPRAY-IONIZATION; POROUS SILICON; DESORPTION/IONIZATION; TISSUE; METABOLOMICS; DISEASE; MALDI; EXPRESSION; PROTEOME; PLATFORM;

D O I：

10.1021/ac101565f

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Nanostructure-Initiator Mass Spectrometry (NIMS) is a matrix-free desorption/ionization approach that is particularly well-suited for unbiased (untargeted) metabolomics. An overview of the NIMS technology and its application in the detection of biofluid and tissue metabolites are presented. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.httnl.)

引用

页码：2 / 7

页数：6

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