Filtering of Visual Information in the Tectum by an Identified Neural Circuit

被引：179

作者：

Del Bene, Filippo ^{[3
]}

Wyart, Claire ^{[1
,2
]}

Robles, Estuardo ^{[3
]}

Tran, Amanda ^{[3
]}

Looger, Loren ^{[4
]}

Scott, Ethan K. ^{[3
]}

Isacoff, Ehud Y. ^{[1
,2
,5
,6
]}

Baier, Herwig ^{[3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[4] Howard Hughes Med Inst, Ashburn, VA 20147 USA

[5] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

[6] Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

SCIENCE | 2010年 / 330卷 / 6004期

基金：

美国国家科学基金会;

关键词：

ZEBRAFISH OPTIC TECTUM; SUPERIOR COLLICULUS; LARVAL ZEBRAFISH; IN-VIVO; ENHANCER; CELLS;

D O I：

10.1126/science.1192949

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter gamma-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.

引用

页码：669 / 673

页数：5

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