Overview of MicroRNA Biology

被引：1084

作者：

Mohr, Ashley M. ^{[1
]}

Mott, Justin L. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

SEMINARS IN LIVER DISEASE | 2015年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ribonucleoprotein; long noncoding RNA; RNAi; microRNA; alternatives to seed binding; NONCODING RNA; MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; ALTERNATIVE POLYADENYLATION; MAMMALIAN MICRORNAS; 3' ADENYLATION; TARGET SITES; EXPRESSION; CANCER; LET-7;

D O I：

10.1055/s-0034-1397344

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of messenger RNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA. However, microRNA function is more complicated and nuanced than this "on-off" model would suggest. Further, many microRNA targets are themselves noncoding RNAs. In this review, the authors discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.

引用

页码：3 / 11

页数：9

共 73 条

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