Overview of MicroRNA Biology

被引：1084

作者：

Mohr, Ashley M. ^{[1
]}

Mott, Justin L. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

SEMINARS IN LIVER DISEASE | 2015年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ribonucleoprotein; long noncoding RNA; RNAi; microRNA; alternatives to seed binding; NONCODING RNA; MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; ALTERNATIVE POLYADENYLATION; MAMMALIAN MICRORNAS; 3' ADENYLATION; TARGET SITES; EXPRESSION; CANCER; LET-7;

D O I：

10.1055/s-0034-1397344

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of messenger RNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA. However, microRNA function is more complicated and nuanced than this "on-off" model would suggest. Further, many microRNA targets are themselves noncoding RNAs. In this review, the authors discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.

引用

页码：3 / 11

页数：9

共 73 条

[61] Exosomes and free will: Is there any rapport?
Jagla, Fedor
Lakota, Jan
Pechanova, Olga
[J]. ACTIVITAS NERVOSA SUPERIOR REDIVIVA, 2022, 64 (01): : 1 - 2
[62] High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
Tierling, S
Dalbert, S
Schoppenhorst, S
Tsai, CE
Oliger, S
Ferguson-Smith, AC
Paulsen, M
Walter, J
[J]. GENOMICS, 2006, 87 (02) : 225 - 235
[63] Coordinated Post-transcriptional Regulation of Hsp70.3 Gene Expression by MicroRNA and Alternative Polyadenylation
Tranter, Michael
Helsley, Robert N.
Paulding, Waltke R.
McGuinness, Michael
Brokamp, Cole
Haar, Lauren
Liu, Yong
Ren, Xiaoping
Jones, W. Keith
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (34) : 29828 - 29837
[64] Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Valadi, Hadi
Ekstrom, Karin
Bossios, Apostolos
Sjostrand, Margareta
Lee, James J.
Lotvall, Jan O.
[J]. NATURE CELL BIOLOGY, 2007, 9 (06) : 654 - U72
[65] Valadkhan S, 2013, ESSAYS BIOCHEM, V54, P79, DOI [10.1042/BSE0540079, 10.1042/bse0540079]
[66] Switching from repression to activation: MicroRNAs can up-regulate translation
Vasudevan, Shobha
Tong, Yingchun
Steitz, Joan A.
[J]. SCIENCE, 2007, 318 (5858) : 1931 - 1934
[67] Targeted deletion reveals essential and overlapping functions of the miR-17∼92 family of miRNA clusters
Ventura, Andrea
Young, Amanda G.
Winslow, Monte M.
Lintault, Laura
Meissner, Alex
Erkeland, Stefan J.
Newman, Jamie
Bronson, Roderick T.
Crowley, Denise
Stone, James R.
Jaenisch, Rudolf
Sharp, Phillip A.
Jacks, Tyler
[J]. CELL, 2008, 132 (05) : 875 - 886
[68] Wang T, 2014, TUMOUR BIOL
[69] Alternative Processing of Primary microRNA Transcripts by Drosha Generates 5′ End Variation of Mature microRNA
Wu, Haoquan
Ye, Chunting
Ramirez, Danielle
Manjunath, N.
[J]. PLOS ONE, 2009, 4 (10):
[70] Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
Yang, WD
Chendrimada, TP
Wang, QD
Higuchi, M
Seeburg, PH
Shiekhattar, R
Nishikura, K
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (01) : 13 - 21

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