Heme oxygenase-1 and carbon monoxide in vascular pathobiology

被引：267

作者：

Dulak, Jozef ^{[3
]}

Deshane, Jessy ^{[2
]}

Jozkowicz, Alicja ^{[3
]}

Agarwal, Anupam ^{[1
,2
]}

机构：

[1] Univ Alabama, Div Nephrol, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Med, Ctr Nephrol Res & Training, Ctr Free Rad Biol,Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

[3] Jagiellonian Univ, Dept Med Biotechnol, Fac Biochem Biophys & biotechnol, Krakow, Poland

来源：

CIRCULATION | 2008年 / 117卷 / 02期

基金：

英国惠康基金;

关键词：

angiogenesis; antioxidants; endothelium; vasculature; growth substances; hypoxia; nitric oxide;

D O I：

10.1161/CIRCULATIONAHA.107.698316

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis involves the formation of new blood vessels and is critical for fundamental events such as development and repair after injury. Perturbances in angiogenesis contribute to the pathogenesis of diverse clinical conditions including cancer, complications of diabetes mellitus, ischemia/reperfusion injury of the heart and other organs, and preeclampsia, as well as a number of inflammatory disorders. Recent work has identified heme oxygenase-1 and its gaseous product, carbon monoxide, to possess potent proangiogenic properties in addition to well-recognized antiinflammatory, antioxidant, and antiapoptotic effects. Angiogenic factors, such as vascular endothelial growth factor and stromal cell-derived factor-1, mediate their proangiogenic effects through induction of heme oxygenase-1, making it an attractive target for therapeutic intervention. This review will provide an overview of the role of heme oxygenase-1 and carbon monoxide in angiogenesis.

引用

页码：231 / 241

页数：11

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