The origin of FOXP3-expressing CD4+ regulatory T cells:: thymus or periphery

被引：174

作者：

Sakaguchi, S

机构：

[1] Kyoto Univ, Dept Expt Pathol, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan

[2] RIKEN, Immunopathol Lab, Res Ctr Allergy & Immunol, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 09期

关键词：

D O I：

10.1172/JCI200320274

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Naturally arising CD4(+) regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4(+) T cells in humans, it is now possible to determine their origin and developmental pathway (see the related article beginning on page 1437).

引用

收藏

页码：1310 / 1312

页数：3

相关论文

共 21 条

[1] Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment [J].

Annacker, O ;

Burlen-Defranoux, O ;

Pimenta-Araujo, R ;

Cumano, A ;

Bandeira, A .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3573-3580

[2] Origin of regulatory T cells with known specificity for antigen [J].

Apostolou, I ;

Sarukhan, A ;

Klein, L ;

von Boehmer, H .

NATURE IMMUNOLOGY, 2002, 3 (08) :756-763

[3] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[4] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

[5] JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome [J].

Chatila, TA ;

Blaeser, F ;

Ho, N ;

Lederman, HM ;

Voulgaropoulos, C ;

Helms, C ;

Bowcock, AM .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (12) :R75-R81

[6] Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].

Fontenot, Jason D. ;

Gavin, Marc A. ;

Rudensky, Alexander Y. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992

[7] Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis [J].

Gambineri, E ;

Torgerson, TR ;

Ochs, HD .

CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (04) :430-435

[8] Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo [J].

Gavin, MA ;

Clarke, SR ;

Negrou, E ;

Gallegos, A ;

Rudensky, A .

NATURE IMMUNOLOGY, 2002, 3 (01) :33-41

[9] Control of regulatory T cell development by the transcription factor Foxp3 [J].

Hori, S ;

Nomura, T ;

Sakaguchi, S .

SCIENCE, 2003, 299 (5609) :1057-1061

[10] An essential role for Scurfin in CD4+CD25+ T regulatory cells [J].

Khattri, R ;

Cox, T ;

Yasayko, SA ;

Ramsdell, F .

NATURE IMMUNOLOGY, 2003, 4 (04) :337-342