The origin of FOXP3-expressing CD4+ regulatory T cells:: thymus or periphery

被引：175

作者：

Sakaguchi, S

机构：

[1] Kyoto Univ, Dept Expt Pathol, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan

[2] RIKEN, Immunopathol Lab, Res Ctr Allergy & Immunol, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 09期

关键词：

D O I：

10.1172/JCI200320274

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Naturally arising CD4(+) regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4(+) T cells in humans, it is now possible to determine their origin and developmental pathway (see the related article beginning on page 1437).

引用

页码：1310 / 1312

页数：3