C1q-binding proteins and C1q receptors

被引：49

作者：

Nicholson-Weller, A

Klickstein, LB

机构：

[1] Harvard Univ, Sch Med, Div Allergy, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)80008-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aggregated or immobilized complement Clq induces cellular responses in many different cell types. Clq-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1 q-deficient humans have infectious complications and a very high incidence of autoimmune disease. The search for the Clq receptor(s), which has been ongoing for 25 years. has led recently to the recognition that proteins identified as binding to C1q may be divided into two groups: Clq-binding molecules that are normally intracellular; and cell surface Clq receptors.

引用

页码：42 / 46

页数：5

共 47 条

[1] Development of systemic lupus erythematosus in a patient with selective complete C1q deficiency [J].