Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method.

被引：17

作者：

Bussolari, JC ^{[1
]}

Rehborn, DC ^{[1
]}

Combs, DW ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Discovery, Raritan, NJ 08869 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(98)02598-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solution phase synthesis for the preparation of libraries of 2-substituted phenylpropyl amines and amides was accomplished using dihydrocoumarins as a useful synthon in parallel synthesis. Resin quench methods were utilized in the purifications of the amides and a resin quench-capture method was utilized in metallo-organic reductions leading to the targeted phenylpropyl amines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1241 / 1244

页数：4

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