Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D

被引：254

作者：

Stern-Ginossar, Noam ^{[1
]}

Gur, Chamutal ^{[1
]}

Biton, Moshe ^{[1
]}

Horwitz, Elad ^{[1
]}

Elboim, Moran ^{[1
]}

Stanietsky, Noa ^{[1
]}

Mandelboim, Michal ^{[2
]}

Mandelboim, Ofer ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Biomed Res Inst, Hadassah Med Sch, IL-91120 Jerusalem, Israel

[2] Clin Virol Unit, IL-52621 Ramat Gan, Israel

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 09期

基金：

以色列科学基金会;

关键词：

D O I：

10.1038/ni.1642

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A microRNA encoded by human cytomegalovirus downregulates MICB expression by targeting a specific site in the MICB 3' untranslated region. As this site is conserved among different MICB alleles and a similar site exists in the MICA 3' untranslated region, we speculated that these sites are targeted by cellular microRNAs. Here we identified microRNAs that bound to these MICA and MICB 3' untranslated region sequences and obtained data suggesting that these microRNAs maintain expression of MICA and MICB protein under a certain threshold and facilitate acute upregulation of MICA and MICB during cellular stress. These microRNAs were overexpressed in various tumors and we demonstrate here that they aided tumor avoidance of immune recognition.

引用

页码：1065 / 1073

页数：9

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