An evolutionary approach reveals a high protein-coding capacity of the human genome

被引：28

作者：

Nekrutenko, A

Chung, WY

Li, WH

机构：

[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[2] Acad Sinica, Inst Informat Sci, Taipei 115, Taiwan

[3] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 06期

关键词：

D O I：

10.1016/S0168-9525(03)00114-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We developed a new evolutionary method for identifying exons from genomic sequences and found 19 000 potential coding exons that are absent from all existing annotations of the human genome. Of these, 13 700 satisfied very stringent criteria and can with confidence be considered as novel exons. Evidently, a large number of new human genes can be identified using evolutionary approaches.

引用

页码：306 / 310

页数：5

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