Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models

被引：62

作者：

Gao, Jian Ping ^{[1
]}

Chen, Chang Xun ^{[1
]}

Gu, Wei Liang ^{[1
]}

Wu, Qi ^{[1
]}

Wang, Ying ^{[1
]}

Lue, Jian ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Dept Pharmacol, Shanghai 201203, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Polydatin; Ventricular remodeling; Blood pressure; Neurohormone; RENIN-ANGIOTENSIN-ALDOSTERONE; HEART-FAILURE; CARDIAC-HYPERTROPHY; BLOOD-PRESSURE; HYPERTENSION; RESVERATROL; SYSTEM; INJURY; MASS; 3,4',5-TRIHYDROXYSTIBENE-3-BETA-MONO-D-GLUCOSIDE;

D O I：

10.1016/j.fitote.2010.06.023

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The study was designed to examine the effects of polydatin on ventricular remodeling induced by isoproterenol in mice and by abdominal aortic banding in rats. Polydatin reduced cardiac weight indexes in mice and rats, lowered the contents of cyclic AMP and angiotensin II in mice. It also decreased the size of cardiomyocyte, the levels of aldosterone, tumor necrosis factor-alpha, angiotensin II and endothelin-1, reduced ventricular collagen volume and decreased blood pressure in rats. The results demonstrate that polydatin has the beneficial effects on attenuating ventricular remodeling, which are associated with its inhibiting the activation of neurohormone, especially in rennin-angiotensin-aldosterone system. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：953 / 960

页数：8

共 42 条

[1]

Pathophysiologic role of the renin-angiotensin-aldosterone and sympathetic nervous systems in heart failure [J].