Enantioselective inclusion between terbutaline enantiomers and hydroxypropyl-β-cyclodextrin

被引：13

作者：

Kim, KH ^{[1
]}

Park, YH

机构：

[1] Kangweon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

[2] Hanmi Pharmaceut, Cent Res Inst, Hajeori 445910, Hwasung Gun, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 175卷 / 02期

关键词：

enantiomer; enantioselective binding; HP-beta-CD; H-1 NMR spectroscopy; stability constants; terbutaline;

D O I：

10.1016/S0378-5173(98)00278-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solid inclusion complexes between terbutaline (racemate, S-(+)-enantiomer, and R-(-)-enantiomer, respectively) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were prepared by the lyophilization method. Characterization of each complex was achieved with differential scanning calorimetry (DSC). Stoichiometry between terbutaline and HP-beta-CD was studied by UV spectroscopy, and stability constants between terbutaline (racemic, S-(+)-enantiomer and R-(-)-enantiomer) and HP-beta-CD was also determined by UV absorption and chromatographic retention method. Structural study to confirm exact location of chiral discrimination between terbutaline enantiomers and HP-beta-CD was performed by H-1 NMR spectroscopy. From this experiment, enantioselective binding of terbutaline enantiomers to HP-beta-CD was clearly demonstrated. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：247 / 253

页数：7

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