Cell microarrays and RNA interference chip away at gene function

被引：135

作者：

Wheeler, DB

Carpenter, AE

Sabatini, DM

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / Suppl 6期

关键词：

D O I：

10.1038/ng1560

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The recent development of cell microarrays offers the potential to accelerate high-throughput functional genetic studies. The widespread use of RNA interference (RNAi) has prompted several groups to fabricate RNAi cell microarrays that make possible discrete, in-parallel transfection with thousands of RNAi reagents on a microarray slide. Though still a budding technology, RNAi cell microarrays promise to increase the efficiency, economy and ease of genome-wide RNAi screens in metazoan cells.

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收藏

页码：S25 / S30

页数：6

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