Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

被引：1048

作者：

Cavallaro, U

Christofori, G ^{[1
]}

机构：

[1] Univ Basel, Dept Clin Biol Sci, Inst Biochem & Genet, CH-4003 Basel, Switzerland

[2] IFOM FIRC Inst Mol Oncol, Milan, Italy

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrc1276

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In addition to their adhesive functions, cell-adhesion molecules modulate signal-transduction pathways by interacting with molecules such as receptor tyrosine kinases, components of the WNT signalling pathway and RHO-family GTPases. So, changes in the expression of cell-adhesion molecules affect not only the adhesive repertoire of a cell, but also its signal-transduction status. Conversely, signalling pathways can modulate the function of cell-adhesion molecules, altering the interactions between cells and their environment. Recent experimental evidence indicates that such processes have a crucial role in tumour progression, in particular during invasion and metastasis.

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页码：118 / 132

页数：15

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