Of mice and men: experimental autoimmune encephalitis and multiple sclerosis

被引：28

作者：

Handel, Adam E. ^{[1
,2
]}

Lincoln, Matthew R. ^{[1
,2
,3
]}

Ramagopalan, Sreeram V. ^{[1
,2
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Univ Oxford, Dept Clin Neurol, John Radcliffe Hosp, Oxford OX3 7BN, England

[3] Univ Toronto, Fac Med, Toronto, ON M5S 1A8, Canada

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 41卷 / 11期

关键词：

Experimental autoimmune encephalitis; Multiple sclerosis; Modelling complex disease; Literature analysis; T-CELL-RECEPTOR; ANIMAL-MODELS; B-CELLS; ENCEPHALOMYELITIS; THERAPY; DISEASE; LOCI;

D O I：

10.1111/j.1365-2362.2011.02519.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background Research using experimental autoimmune encephalitis (EAE) models accounts for almost 20% of the papers. published in multiple sclerosis (MS). Methods We performed a literature review of papers indexed with ISI Web of Science on EAE and MS over the last 30 years and a detailed analysis of studies of molecular pathways in EAE published in 2008 and 2009. Results The impact of EAE studies declines more rapidly than other studies published on MS (EAE cited corrected half-life = 4.00 years vs. MS cited corrected half-life = 9.66 years, P < 0.0001). The pathology of EAE differs quite markedly from that observed in the human disease. EAE has implicated many different genes as important to pathogenesis but only a minority of these are supported by human studies. Conclusions Future research should critically appraise precisely what is being modelled by EAE before drawing conclusions about human disease.

引用

页码：1254 / 1258

页数：5

共 21 条

[11]

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell B cell cooperation [J].