Antagonists of the human adenosine A2A receptor.: Part 3:: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d] pyrimidines and 6-arylpurines

被引：60

作者：

Gillespie, Roger J.

Cliffe, Ian A.

Dawson, Claire E.

Dourish, Colin T.

Gaur, Suneel

Jordan, Allan M. ^{[1
]}

Knight, Antony R.

Lerpiniere, Joanne

Misra, Anil

Pratt, Robert M.

Roffey, Jonathan

Stratton, Gemma C.

Upton, Rebecca

Weiss, Scott M.

Williamson, Douglas S. ^{[1
]}

机构：

[1] Vernalis R&D Ltd, Cambridge CB21 6GB, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 09期

关键词：

adenosine A(2A) receptor antagonists; Parkinson's disease; pyrazolo[3,4-d] pyrimidine; pyrrolo[2,3-d] pyrimidine; purine;

D O I：

10.1016/j.bmcl.2008.03.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2924 / 2929

页数：6

共 15 条

[11] Adenosine A(2) receptors modulate haloperidol-induced catalepsy in rats [J].