Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century

被引:243
作者
Collier, RJ [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
关键词
toxin; ADP-Ribosylation; translocation; receptor;
D O I
10.1016/S0041-0101(01)00165-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diphtheria toxin is one of the most extensively studied and well understood bacterial toxins. Ever since its discovery in the late 1800's this toxin has occupied a central focus in the field of toxinology. In this review, I present a chronology of major discoveries that led to our current understanding of the structure and activity of diphtheria toxin. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1793 / 1803
页数:11
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