Adipocyte cholesterol balance in obesity

被引：72

作者：

Le Lay, S ^{[1
]}

Ferré, P ^{[1
]}

Dugail, I ^{[1
]}

机构：

[1] Inst Biomed Cordeliers, INSERM U465, F-75006 Paris, France

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

cholesterol traffic; fat cell; gene expression; lipid droplet; sterol-response-element-binding protein (SREBP); triacylglycerol;

D O I：

10.1042/BST0320103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adipose tissue is specialized in the storage of energy in the form of triacylglycerol. Within the fat cell, triacylglycerols are found in a well-defined structural compartment called the lipid droplet, which occupies the vast majority of the fat cell volume. However, many other lipids are present in the lipid droplet. These include sterols, carotenoids, cholecalciferol and lipophilic toxic pollutants of the environment such as dioxins and tocopheirols. The topic of this article is the role of fat cell cholesterol in adipose tissue physiology and its potential implication in pathological states such as obesity.

引用

页码：103 / 106

页数：4

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