Polyionic drug-sensitive membrane electrodes: Principles and practice

被引：8

作者：

Fu, B

Yun, JH

Wahr, J

Meyerhoff, ME

Yang, VC

机构：

[1] UNIV MICHIGAN, DEPT CHEM, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

[3] UNIV MICHIGAN, DEPT ANESTHESIOL, ANN ARBOR, MI 48109 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1996年 / 21卷 / 03期

基金：

美国国家卫生研究院;

关键词：

heparin; protamine; protease activity; ion-selective electrode (ISE); potentiometric sensors; protamine titration; macromolecular binding constants;

D O I：

10.1016/S0169-409X(96)00409-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent advances in the design and applications of polymer membrane-based potentiometric sensors for measuring polyionic drugs (i.e. heparin and protamine) are reviewed. The underlying principles for potentiometric polyion sensing are described. The utility of newly developed heparin and protamine sensors is demonstrated via both fundamental and practical applications.

引用

页码：215 / 223

页数：9

共 24 条

[1] CHEMICAL SENSORS FOR BEDSIDE MONITORING OF CRITICALLY ILL PATIENTS [J].