Interleukin-18 in Pulmonary Inflammatory Diseases

被引：38

作者：

Kawayama, Tomotaka ^{[1
]}

Okamoto, Masaki ^{[1
]}

Imaoka, Haruki ^{[1
]}

Kato, Seiya ^{[2
,3
]}

Young, Howard A. ^{[4
]}

Hoshino, Tomoaki ^{[1
]}

机构：

[1] Kurume Univ, Div Respirol Neurol & Rheumatol, Dept Med 1, Sch Med, Kurume, Fukuoka 8300011, Japan

[2] Univ Ryukyus, Grad Sch, Div Pathol & Cell Biol, Okinawa, Japan

[3] Univ Ryukyus, Fac Med, Okinawa, Japan

[4] Frederick Natl Lab Canc Res, LEI, Frederick, MD USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2012年 / 32卷 / 10期

关键词：

IDIOPATHIC INTERSTITIAL PNEUMONIAS; IFN-GAMMA PRODUCTION; ACUTE LUNG INJURY; T-CELLS; LEGIONELLA-PNEUMOPHILA; ALLERGIC-ASTHMA; INNATE IMMUNITY; POTENTIAL ROLE; CUTTING EDGE; IL-18;

D O I：

10.1089/jir.2012.0029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proinflammatory cytokine interleukin (IL)-18 was originally discovered as an interferon-g-inducing factor in 1995. IL-18 is known to play an important role in Th1/Tc1 polarization and promoting the production of Th2 cytokines (e. g., IL-4, IL-5, IL-9, and IL-13) by T cells, NK cells, basophils, and mast cells. IL-18 can act as a cofactor for Th2 cell development and IgE production, and also plays an important role in the differentiation of Th17 cells. IL-18 is a key player in the pathogenesis of inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, adult-onset Still's disease, Sjogren's syndrome, and inflammatory bowel diseases. Furthermore, many lines of evidence suggest that IL-18 plays a key role in the pathogenesis of pulmonary inflammatory diseases, including bronchial asthma and chronic obstructive pulmonary disease. Here, we review the pathological roles of IL-18 in pulmonary inflammatory diseases.

引用

页码：443 / 449

页数：7

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