Evolving biosynthetic tangos negotiate mechanistic landscapes

被引：49

作者：

Austin, Michael B. ^{[1
]}

O'Maille, Paul E. ^{[1
]}

Noel, Joseph P. ^{[1
]}

机构：

[1] Jack H Skirball Ctr Chem Biol & Prot, Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 04期

关键词：

D O I：

10.1038/nchembio0408-217

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dependence of polyketide synthase and terpene cyclase mechanistic adaptation on the chemistry of their oligomeric substrates illuminates a convergent evolutionary strategy for shaping cyclization in these otherwise disparate reactions. Evolution of these enzyme families relies on rhythmic tangos, in which the enzymes and substrates together determine product outcome by negotiating decision networks governing intrinsic and induced chemical reactivities.

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收藏

页码：217 / 222

页数：6

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