One pathway, many products

被引：138

作者：

Fischbach, Michael A. ^{[1
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 07期

关键词：

METABOLITES NATURAL-PRODUCTS; GIBBERELLIN BIOSYNTHESIS; EVOLUTION; DIVERSITY; PLANTS; FUNGI; MODEL;

D O I：

10.1038/nchembio0707-353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biosynthetic pathways for secondary metabolites usually make many products, not just one. In this Commentary, we consider why molecular promiscuity might be an evolutionarily advantageous feature of these pathways.

引用

页码：353 / 355

页数：3

共 15 条

[1] The guanacastepenes: A highly diverse family of secondary metabolites produced by an endophytic fungus [J].

Brady, SF ;

Bondi, SM ;

Clardy, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (40) :9900-9901

[2] Endless forms: the evolution of gene regulation and morphological diversity [J].

Carroll, SB .

CELL, 2000, 101 (06) :577-580

[3] Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP [J].

Choi, JW ;

Chen, J ;

Schreiber, SL ;

Clardy, J .

SCIENCE, 1996, 273 (5272) :239-242

[4] Do we need a new hypothesis to explain plant VOC emissions? [J].

Firn, RD ;

Jones, CG .

TRENDS IN PLANT SCIENCE, 2006, 11 (03) :112-113

[5] Natural products - a simple model to explain chemical diversity [J].

Firn, RD ;

Jones, CG .

NATURAL PRODUCT REPORTS, 2003, 20 (04) :382-391

[6] The evolution of secondary metabolism - a unifying model [J].

Firn, RD ;

Jones, CG .

MOLECULAR MICROBIOLOGY, 2000, 37 (05) :989-994

[7] Gibberellin biosynthesis in plants and fungi: A case of convergent evolution? [J].

Hedden, P ;

Phillips, AL ;

Rojas, MC ;

Carrera, E ;

Tudzynski, B .

JOURNAL OF PLANT GROWTH REGULATION, 2001, 20 (04) :319-331

[8] Biosynthetic diversity in plant triterpene cyclization [J].

Phillips, Dereth R. ;

Rasbery, Jeanne M. ;

Bartel, Bonnie ;

Matsuda, Seiichi P. T. .

CURRENT OPINION IN PLANT BIOLOGY, 2006, 9 (03) :305-314

[9] How gibberellin regulates plant growth and development: A molecular genetic analysis of gibberellin signaling [J].

Richards, DE ;

King, KE ;

Ait-ali, T ;

Harberd, NP .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 2001, 52 :67-88

[10] ON THE EVOLUTION OF FUNCTIONAL SECONDARY METABOLITES (NATURAL-PRODUCTS) [J].

STONE, MJ ;

WILLIAMS, DH .

MOLECULAR MICROBIOLOGY, 1992, 6 (01) :29-34

← 1 2 →