PFK-2/FBPase-2:: maker and breaker of the essential biofactor fructose-2, 6-bisphosphate

被引：297

作者：

Okar, DO ^{[1
]}

Manzano, A

Navarro-Sabatè, A

Riera, L

Bartrons, R

Lange, AJ

机构：

[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

[2] Univ Barcelona, Unitat Bioquim, Barcelona 08907, Spain

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(00)01699-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver,This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes, Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology, Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.

引用

页码：30 / 35

页数：6

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