Peptidoglycan composition of vancomycin-resistant Enterococcus faecium

被引：13

作者：

deJonge, BLM ^{[1
]}

Gage, D ^{[1
]}

Handwerger, S ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV,DEPT BIOCHEM,NATL INST HLTH,MASS SPECTROMETRY FACIL,E LANSING,MI 48824

来源：

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE | 1996年 / 2卷 / 02期

关键词：

D O I：

10.1089/mdr.1996.2.225

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Muropeptide composition of peptidoglycan isolated from isogenic vancomycin-resistant and -sensitive Enterococcus faecium strains was analyzed by reverse-phase high-performance liquid chromatography combined with amino acid and fast atom bombardment mass spectrometric analyses, Peptidoglycan of the sensitive and resistant strains was the same and was composed of tri- and tetrapeptides stem peptide subunits with or without aspartate or asparagine substitutions on the epsilon-amino group of the lysine residue, Thus, the synthesis of lactate-terminating peptidoglycan precursors in vancomycin-resistant E. faecium did not affect the chemical composition of peptidoglycan.

引用

页码：225 / 229

页数：5