Caveolins and membrane cholesterol

被引:40
作者
Ikonen, E
Heino, S
Lusa, S
机构
[1] Natl Publ Hlth Inst, Biomedicum, Dept Mol Nucl, Helsinki 00251, Finland
[2] Univ Helsinki, Inst Biotechnol, Helsinki 00251, Finland
关键词
caveolae; cholesterol; intracellular transport; membrane domain;
D O I
10.1042/BST0320121
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Caveolae (small plasma membrane invaginations) and their coat proteins, caveolins, have attracted the attention of researchers in diverse fields, including cell biology, cardiovascular and cancer research. The tight association between caveolin and cholesterol governs the biochemical behaviour of caveolae and is emerging as an important characteristic in a number of processes assigned to these multifunctional organelles. in this review, selected aspects of the caveolin-cholesterol association and its potential functional implications are discussed.
引用
收藏
页码:121 / 123
页数:3
相关论文
共 35 条
[1]   New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport [J].
Brewer, HB ;
Santamarina-Fojo, S .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (7A) :3E-11E
[2]   STUDIES ON BLOOD CAPILLARIES .2. TRANSPORT OF FERRITIN MOLECULES ACROSS WALL OF MUSCLE CAPILLAIRES [J].
BRUNS, RR ;
PALADE, GE .
JOURNAL OF CELL BIOLOGY, 1968, 37 (02) :277-&
[3]   In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation [J].
Bucci, M ;
Gratton, JP ;
Rudic, RD ;
Acevedo, L ;
Roviezzo, F ;
Cirino, G ;
Sessa, WC .
NATURE MEDICINE, 2000, 6 (12) :1362-1367
[4]   Visualizing caveolin-1 and HDL in cholesterol-loaded aortic endothelial cells [J].
Chao, WT ;
Fan, SS ;
Chen, JK ;
Yang, VC .
JOURNAL OF LIPID RESEARCH, 2003, 44 (06) :1094-1099
[5]   Apo Al/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains [J].
Drobnik, W ;
Borsukova, H ;
Böttcher, A ;
Pfeiffer, A ;
Liebisch, G ;
Schütz, GJ ;
Schindler, H ;
Schmitz, G .
TRAFFIC, 2002, 3 (04) :268-278
[6]   CAVEOLAE AND SORTING IN THE TRANS-GOLGI NETWORK OF EPITHELIAL-CELLS [J].
DUPREE, P ;
PARTON, RG ;
RAPOSO, G ;
KURZCHALIA, TV ;
SIMONS, K .
EMBO JOURNAL, 1993, 12 (04) :1597-1605
[7]   Mechanism of caveolin filament assembly [J].
Fernandez, I ;
Ying, YS ;
Albanesi, J ;
Anderson, RGW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :11193-11198
[8]   Relationship between cholesterol trafficking and signaling in rafts and caveolae [J].
Fielding, CJ ;
Fielding, PE .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1610 (02) :219-228
[9]   DE-NOVO FORMATION OF CAVEOLAE IN LYMPHOCYTES BY EXPRESSION OF VIP21-CAVEOLIN [J].
FRA, AM ;
WILLIAMSON, E ;
SIMONS, K ;
PARTON, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) :8655-8659
[10]   Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface [J].
Heino, S ;
Lusa, S ;
Somerharju, P ;
Ehnholm, C ;
Olkkonen, VM ;
Ikonen, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8375-8380