Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

被引：81

作者：

Yin, Lihua ^{[1
,2
]}

Cheng, Wenxiao ^{[3
]}

Qin, Zishun ^{[3
]}

Yu, Hongdou ^{[3
]}

Yu, Zhanhai ^{[3
]}

Zhong, Mei ^{[3
]}

Sun, Kemo ^{[3
]}

Zhang, Wei ^{[4
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Sch Hosp Stomatol, Dept Oral Implantol, Lanzhou 730000, Gansu, Peoples R China

[3] Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Gansu, Peoples R China

[4] ShanghaiTech Univ, SIAIS, Shanghai 201210, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2015年 / 2015卷

关键词：

BONE; ACTIVATION; SCAFFOLDS; APOPTOSIS; EXTRACTS;

D O I：

10.1155/2015/758706

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 mu M naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 mu M, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.

引用

页数：9

共 25 条

[1]

[Anonymous], NATL GEOGR

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A traditional Chinese medicine formula extracts stimulate proliferation and inhibit mineralization of human mesenchymal stem cells in vitro [J].