National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

被引：1501

作者：

Hyman, Bradley T. ^{[2
]}

Phelps, Creighton H. ^{[3
]}

Beach, Thomas G. ^{[4
]}

Bigio, Eileen H. ^{[5
]}

Cairns, Nigel J. ^{[6
,7
]}

Carrillo, Maria C. ^{[8
]}

Dickson, Dennis W. ^{[9
]}

Duyckaerts, Charles ^{[10
]}

Frosch, Matthew P. ^{[11
]}

Masliah, Eliezer ^{[12
,13
]}

Mirra, Suzanne S. ^{[14
]}

Nelson, Peter T. ^{[15
]}

Schneider, Julie A. ^{[16
,17
,18
]}

Thal, Dietmar Rudolf ^{[19
]}

Thies, Bill ^{[8
]}

Trojanowski, John Q. ^{[20
]}

Vinters, Harry V. ^{[21
,22
]}

Montine, Thomas J. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[3] NIA, Bethesda, MD 20892 USA

[4] Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ USA

[5] Northwestern Univ, Dept Pathol, NW Alzheimer Dis Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[8] Alzheimers Assoc, Chicago, IL USA

[9] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[10] Hop La Pitie Salpetriere, Serv Neuropathol Raymond Escourolle, Paris, France

[11] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA USA

[12] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[13] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

[14] Suny Downstate Med Ctr, Dept Pathol, Brooklyn, NY 11203 USA

[15] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[16] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[17] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[18] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[19] Univ Ulm, Inst Pathol, Neuropathol Lab, Ulm, Germany

[20] Univ Penn, Sch Med, Dept Pathol & Lab Med, Inst Aging,Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[21] Univ Calif Los Angeles, Dept Pathol & Lab Med Neuropathol, Los Angeles, CA USA

[22] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

来源：

ALZHEIMERS & DEMENTIA | 2012年 / 8卷 / 01期

关键词：

Alzheimer's disease; Lewy body disease; Vascular brain injury; Neuropathology; Consensus guidelines; CEREBRAL AMYLOID ANGIOPATHY; LEWY BODY DISEASE; A-BETA-DEPOSITION; FRONTOTEMPORAL LOBAR DEGENERATION; VASCULAR COGNITIVE IMPAIRMENT; BRAINNET EUROPE CONSORTIUM; MEDIAL TEMPORAL-LOBE; NEUROFIBRILLARY TANGLES; DIAGNOSTIC GUIDELINES; HIPPOCAMPAL SCLEROSIS;

D O I：

10.1016/j.jalz.2011.10.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation. (C) 2012 The Alzheimer's Association. All rights reserved.

引用

页码：1 / 13

页数：13

共 106 条

[21] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[22] Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].

Braak, Heiko ;

Alafuzoff, Irina ;

Arzberger, Thomas ;

Kretzschmar, Hans ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404

[23] Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years [J].

Braak, Heiko ;

Thal, Dietmar R. ;

Ghebremedhin, Estifanos ;

Del Tredici, Kelly .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2011, 70 (11) :960-969

[24] The pathological process underlying Alzheimer's disease in individuals under thirty [J].

Braak, Heiko ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2011, 121 (02) :171-181

[25] Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration [J].

Cairns, Nigel J. ;

Bigio, Eileen H. ;

Mackenzie, Ian R. A. ;

Neumann, Manuela ;

Lee, Virginia M. -Y. ;

Hatanpaa, Kimmo J. ;

White, Charles L., III ;

Schneider, Julie A. ;

Grinberg, Lea Tenenholz ;

Halliday, Glenda ;

Duyckaerts, Charles ;

Lowe, James S. ;

Holm, Ida E. ;

Tolnay, Markus ;

Okamoto, Koichi ;

Yokoo, Hideaki ;

Murayama, Shigeo ;

Woulfe, John ;

Munoz, David G. ;

Dickson, Dennis W. ;

Ince, Paul G. ;

Trojanowski, John Q. ;

Mann, David M. A. .

ACTA NEUROPATHOLOGICA, 2007, 114 (01) :5-22

[26] Amyloid load in nondemented brains correlates with APOE e4 [J].

Caselli, Richard J. ;

Walker, Douglas ;

Sue, Lucia ;

Sabbagh, Marwan ;

Beach, Thomas .

NEUROSCIENCE LETTERS, 2010, 473 (03) :168-171

[27] Cognitive impact of subcortical vascular and Alzheimer's disease pathology [J].

Chui, Helena C. ;

Zarow, Chris ;

Mack, Wendy J. ;

Ellis, William G. ;

Zheng, Ling ;

Jagust, William J. ;

Mungas, Dan ;

Reed, Bruce R. ;

Kramer, Joel H. ;

DeCarli, Charles C. ;

Weiner, Michael W. ;

Vinters, Harry V. .

ANNALS OF NEUROLOGY, 2006, 60 (06) :677-687

[28] A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1 [J].

Crook, R ;

Verkkoniemi, A ;

Perez-Tur, J ;

Mehta, N ;

Baker, M ;

Houlden, H ;

Farrer, M ;

Hutton, M ;

Lincoln, S ;

Hardy, J ;

Gwinn, K ;

Somer, M ;

Paetau, A ;

Kalimo, H ;

Ylikoski, R ;

Pöyhönen, M ;

Kucera, S ;

Haltia, M .

NATURE MEDICINE, 1998, 4 (04) :452-455

[29] CLINICOPATHOLOGIC STUDIES IN DEMENTIA - NONDEMENTED SUBJECTS WITH PATHOLOGICALLY CONFIRMED ALZHEIMERS-DISEASE [J].

CRYSTAL, H ;

DICKSON, D ;

FULD, P ;

MASUR, D ;

SCOTT, R ;

MEHLER, M ;

MASDEU, J ;

KAWAS, C ;

ARONSON, M ;

WOLFSON, L .

NEUROLOGY, 1988, 38 (11) :1682-1687

[30] PATHOLOGICAL MARKERS ASSOCIATED WITH NORMAL AGING AND DEMENTIA IN THE ELDERLY [J].

CRYSTAL, HA ;

DICKSON, DW ;

SLIWINSKI, MJ ;

LIPTON, RB ;

GROBER, E ;

MARKSNELSON, H ;

ANTIS, P .

ANNALS OF NEUROLOGY, 1993, 34 (04) :566-573

← 1 2 3 4 5 6 7 8 9 10 →