Simultaneous MR/PET imaging of the human brain: Feasibility study

被引：365

作者：

Schlemmer, Heinz-Peter W. ^{[1
]}

Pichler, Bernd J. ^{[1
]}

Schmand, Matthias ^{[2
]}

Burbar, Ziad ^{[2
]}

Michel, Christian ^{[2
]}

Ladebeck, Ralf ^{[3
]}

Jattke, Kirstin ^{[3
]}

Townsend, David ^{[4
]}

Nahmias, Claude ^{[4
]}

Jacob, Pradeep K. ^{[5
]}

Heiss, Wolf-Dieter ^{[6
]}

Claussen, Claus D. ^{[1
]}

机构：

[1] Univ Tubingen Hosp, Dept Diagnost Radiol, D-72076 Tubingen, Germany

[2] Siemens Med Solut, Dept Mol Imaging, Knoxville, TN USA

[3] Siemens Med Solut, Dept Magnet Resonance, Erlangen, Germany

[4] Univ Tennessee, Grad Sch Med, Mol Imaging & Translat Res Program, Knoxville, TN USA

[5] Univ Tennessee, Med Ctr, Dept Radiol, Knoxville, TN USA

[6] Max Planck Inst Neurol Res, Cologne, Germany

来源：

RADIOLOGY | 2008年 / 248卷 / 03期

关键词：

D O I：

10.1148/radiol.2483071927

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging. (C) RSNA, 2008.

引用

页码：1028 / 1035

页数：8

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