Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

被引：722

作者：

Yan, YK ^{[1
]}

Melchart, M ^{[1
]}

Habtemariam, A ^{[1
]}

Sadler, PJ ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 38期

基金：

英国惠康基金;

关键词：

D O I：

10.1039/b508531b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru( II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.

引用

页码：4764 / 4776

页数：13

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