Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups

被引：228

作者：

Rahaim, RJ ^{[1
]}

Maleczka, RE ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol052120n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Room-temperature reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times (30 min) using a combination of palladium(11) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS). Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines.

引用

页码：5087 / 5090

页数：4

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