An unusual mechanism for ligand antagonism

被引：132

作者：

Torigoe, C ^{[1
]}

Inman, JK

Metzger, H

机构：

[1] NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 1998年 / 281卷 / 5376期

关键词：

D O I：

10.1126/science.281.5376.568

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells.

引用

页码：568 / 572

页数：5

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