Assembly of infectious hepatitis C virus particles

被引：342

作者：

Bartenschlager, Ralf ^{[1
]}

Penin, Francois ^{[2
,3
,4
]}

Lohmann, Volker ^{[1
]}

Andre, Patrice ^{[3
,4
,5
,6
]}

机构：

[1] Heidelberg Univ, Dept Infect Dis Mol Virol, D-69120 Heidelberg, Germany

[2] Inst Biol & Chim Prot, CNRS, UMR 5086, Lyon, France

[3] Univ Lyon, Lyon, France

[4] IFR128 BioSci Lyon Geiland, Lyon, France

[5] INSERM, U851, F-69008 Lyon, France

[6] Hosp Civils Lyon, F-69002 Lyon, France

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 02期

基金：

欧洲研究理事会;

关键词：

NONSTRUCTURAL PROTEIN 5A; CORE PROTEIN; LOW-DENSITY; ION-CHANNEL; APOLIPOPROTEIN-E; LIPID DROPLET; P7; PROTEIN; TRANSMEMBRANE DOMAINS; ADAPTER PROTEIN; MEMBRANE-FUSION;

D O I：

10.1016/j.tim.2010.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.

引用

页码：95 / 103

页数：9

共 93 条

[1] Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection [J].

Aizaki, Hideki ;

Morikawa, Kenichi ;

Fukasawa, Masayoshi ;

Hara, Hiromichi ;

Inoue, Yasushi ;

Tani, Hideki ;

Saito, Kyoko ;

Nishijima, Masahiro ;

Hanada, Kentaro ;

Matsuura, Yoshiharu ;

Lai, Michael A. C. ;

Miyamura, Tatsuo ;

Wakita, Takaji ;

Suzuki, Tetsuro .

JOURNAL OF VIROLOGY, 2008, 82 (12) :5715-5724

[2] Characterization of low- and very-low-density hepatitis C virus RNA-containing particles [J].

André, P ;

Komurian-Pradel, F ;

Deforges, S ;

Perret, M ;

Berland, JL ;

Sodoyer, M ;

Pol, S ;

Bréchot, C ;

Paranhos-Baccalà, G ;

Lotteau, V .

JOURNAL OF VIROLOGY, 2002, 76 (14) :6919-6928

[3] Hepatitis C virus particles and lipoprotein metabolism [J].

André, P ;

Perlemuter, G ;

Budkowska, A ;

Bréchot, C ;

Lotteau, V .

SEMINARS IN LIVER DISEASE, 2005, 25 (01) :93-104

[4] Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection [J].

Andreo, Ursula ;

Maillard, Patrick ;

Kalinina, Olga ;

Walic, Marine ;

Meurs, Eliane ;

Martinot, Michele ;

Marcellin, Patrick ;

Budkowska, Agata .

CELLULAR MICROBIOLOGY, 2007, 9 (10) :2445-2456

[5] From structure to function: New insights into hepatitis C virus RNA replication [J].

Appel, N ;

Schaller, T ;

Penin, F ;

Bartenschlager, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (15) :9833-9836

[6] Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly [J].

Appel, Nicole ;

Zayas, Margarita ;

Miller, Sven ;

Krijnse-Locker, Jacomine ;

Schaller, Torsten ;

Friebe, Peter ;

Kallis, Stephanie ;

Engel, Ulrike ;

Bartenschlager, Ralf .

PLOS PATHOGENS, 2008, 4 (03)

[7] Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles [J].

Backes, Perdita ;

Quinkert, Doris ;

Reiss, Simon ;

Binder, Marco ;

Zayas, Margarita ;

Rescher, Ursula ;

Gerke, Volker ;

Bartenschlager, Ralf ;

Lohmann, Volker .

JOURNAL OF VIROLOGY, 2010, 84 (11) :5775-5789

[8] Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes [J].

Bankwitz, Dorothea ;

Steinmann, Eike ;

Bitzegeio, Julia ;

Ciesek, Sandra ;

Friesland, Martina ;

Herrmann, Eva ;

Zeisel, Mirjam B. ;

Baumert, Thomas F. ;

Keck, Zhen-yong ;

Foung, Steven K. H. ;

Pecheur, Eve-Isabelle ;

Pietschmann, Thomas .

JOURNAL OF VIROLOGY, 2010, 84 (11) :5751-5763

[9] Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets [J].

Barba, G ;

Harper, F ;

Harada, T ;

Kohara, M ;

Goulinet, S ;

Matsuura, Y ;

Eder, G ;

Schaff, Z ;

Chapman, MJ ;

Miyamura, T ;

Brechot, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1200-1205

[10] Apolipoprotein E Interacts with Hepatitis C Virus Nonstructural Protein 5A and Determines Assembly of Infectious Particles [J].

Benga, Wagane J. A. ;

Krieger, Sophie E. ;

Dimitrova, Maria ;

Zeisel, Mirjam B. ;

Parnot, Marie ;

Lupberger, Joachim ;

Hildt, Eberhard ;

Luo, Guangxiang ;

McLauchlan, John ;

Baumert, Thomas F. ;

Schuster, Catherine .

HEPATOLOGY, 2010, 51 (01) :43-53

← 1 2 3 4 5 6 7 8 9 10 →