Assembly of infectious hepatitis C virus particles

被引：342

作者：

Bartenschlager, Ralf ^{[1
]}

Penin, Francois ^{[2
,3
,4
]}

Lohmann, Volker ^{[1
]}

Andre, Patrice ^{[3
,4
,5
,6
]}

机构：

[1] Heidelberg Univ, Dept Infect Dis Mol Virol, D-69120 Heidelberg, Germany

[2] Inst Biol & Chim Prot, CNRS, UMR 5086, Lyon, France

[3] Univ Lyon, Lyon, France

[4] IFR128 BioSci Lyon Geiland, Lyon, France

[5] INSERM, U851, F-69008 Lyon, France

[6] Hosp Civils Lyon, F-69002 Lyon, France

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 02期

基金：

欧洲研究理事会;

关键词：

NONSTRUCTURAL PROTEIN 5A; CORE PROTEIN; LOW-DENSITY; ION-CHANNEL; APOLIPOPROTEIN-E; LIPID DROPLET; P7; PROTEIN; TRANSMEMBRANE DOMAINS; ADAPTER PROTEIN; MEMBRANE-FUSION;

D O I：

10.1016/j.tim.2010.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.

引用

页码：95 / 103

页数：9

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