Carcinogenesis, cancer therapy and chemoprevention

被引：81

作者：

Blagosklonny, MV ^{[1
]}

机构：

[1] New York Med Coll, Brander Canc Res Inst, Hawthorne, NY 10532 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2005年 / 12卷 / 06期

关键词：

carcinogenesis; cancer therapy; chemoprevention;

D O I：

10.1038/sj.cdd.4401610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carcinogenesis and cancer therapy are two sides of the same coin, such that the same cytotoxic agent can cause cancer and be used to treat cancer. This review links carcinogenesis, chemoprevention and cancer therapy in one process driven by cytotoxic agents (carcinoagents) that select either for or against cells with oncogenic alterations. By unifying therapy and cancer promotion and by distinguishing nononcogenic and oncogenic mechanisms of resistance, I discuss anticancer- and chemopreventive agent-induced carcinogenesis and tumor progression and, vice versa, carcinogens as anticancer drugs, anticancer drugs as chemopreventive agents and exploiting oncogene-addiction and drug resistance for chemoprevention and cancer therapy.

引用

页码：592 / 602

页数：11

共 155 条

[41] Severe periorbital edema secondary to STI571 (Gleevec)
Esmaeli, B
Prieto, VG
Butler, CE
Kim, SK
Ahmadi, MA
Kantarjian, HM
Talpaz, M
[J]. CANCER, 2002, 95 (04) : 881 - 887
[42] Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
Esteller, M
Garcia-Foncillas, J
Andion, E
Goodman, SN
Hidalgo, OF
Vanaclocha, V
Baylin, SB
Herman, JG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (19) : 1350 - 1354
[43] INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN
EVAN, GI
WYLLIE, AH
GILBERT, CS
LITTLEWOOD, TD
LAND, H
BROOKS, M
WATERS, CM
PENN, LZ
HANCOCK, DC
[J]. CELL, 1992, 69 (01) : 119 - 128
[44] Proliferation, cell cycle and apoptosis in cancer
Evan, GI
Vousden, KH
[J]. NATURE, 2001, 411 (6835) : 342 - 348
[45] Secondary leukemias induced by topoisomerase-targeted drugs
Felix, CA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3): : 233 - 255
[46] Strategies for reversing drug resistance
Fojo, T
Bates, S
[J]. ONCOGENE, 2003, 22 (47) : 7512 - 7523
[47] HUMAN MESOTHELIOMA CELLS AND ASBESTOS-EXPOSED MESOTHELIAL CELLS ARE SELECTIVELY RESISTANT TO AMOSITE TOXICITY - A POSSIBLE MECHANISM FOR TUMOR PROMOTION BY ASBESTOS
GABRIELSON, EW
VANDERMEEREN, A
REDDEL, RR
REDDEL, H
GERWIN, BI
HARRIS, CC
[J]. CARCINOGENESIS, 1992, 13 (08) : 1359 - 1363
[48] Development of c-kit-expressing small-cell lung cancer in a chronic myeloid leukemia patient during imatinib treatment
Gambacorti-Passerini, C
Piazza, R
Tornaghi, L
Pilotti, S
Pogliani, E
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (22): : 1723 - 1724
[49] MGMT: Its role in cancer aetiology and cancer therapeutics
Gerson, SL
[J]. NATURE REVIEWS CANCER, 2004, 4 (04) : 296 - 307
[50] Cancer chemoprevention by dietary constituents: a tale of failure and promise
Gescher, Andreas J.
Sharma, Ricky A.
Steward, William P.
[J]. LANCET ONCOLOGY, 2001, 2 (06) : 371 - 379

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