The Discovery of Salinosporamide K from the Marine Bacterium "Salinispora pacifica" by Genome Mining Gives Insight into Pathway Evolution

被引：52

作者：

Eustaquio, Alessandra S. ^{[1
]}

Nam, Sang-Jip ^{[1
]}

Penn, Kevin ^{[1
]}

Lechner, Anna ^{[1
]}

Wilson, Micheal C. ^{[1
]}

Fenical, William ^{[1
]}

Jensen, Paul R. ^{[1
]}

Moore, Bradley S. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

CHEMBIOCHEM | 2011年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

biosynthesis; genome mining; marine bacteria; proteasome inhibitors; salinosporamides; PROTEASOME; BIOSYNTHESIS; INHIBITOR; TROPICA; COMPLEX; POTENT;

D O I：

10.1002/cbic.201000564

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：61 / 64

页数：4

共 18 条

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