Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

被引：228

作者：

Fenical, William ^{[2
]}

Jensen, Paul R. ^{[2
]}

Palladino, Michael A. ^{[1
]}

Lam, Kin S. ^{[1
]}

Lloyd, G. Kenneth ^{[1
]}

Potts, Barbara C. ^{[1
]}

机构：

[1] Nereus Pharmaceut Inc, San Diego, CA 92121 USA

[2] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 06期

关键词：

Salinosporamide A; NPI-0052; Marine actinomycetes; Proteasome inhibitor; ACTINOMYCETE SALINISPORA-TROPICA; PROTEASOME INHIBITOR NPI-0052; CONCISE TOTAL-SYNTHESIS; 20S PROTEASOME; MULTIPLE-MYELOMA; A NPI-0052; OCEAN SEDIMENTS; CANCER-CELLS; BORTEZOMIB; APOPTOSIS;

D O I：

10.1016/j.bmc.2008.10.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2175 / 2180

页数：6

共 44 条

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