Multiple roles of arginine/serine-rich splicing factors in RNA processing

被引：129

作者：

Sanford, JR ^{[1
]}

Ellis, J ^{[1
]}

Cáceres, JF ^{[1
]}

机构：

[1] MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

基金：

英国医学研究理事会;

关键词：

alternative splicing; pre-mRNA splicing; RNA processing; RS domain; small nuclear ribonucleoprotein (RNP);

D O I：

10.1042/BST0330443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SIR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. in the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.

引用

页码：443 / 446

页数：4

共 41 条

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