Yeast as a model for studying Alzheimer's disease

被引：44

作者：

Bharadwaj, Prashant ^{[2
,3
]}

Martins, Ralph ^{[2
,4
,5
]}

Macreadie, Ian ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sienna Canc Diagnost, Inst Bio21, Parkville, Vic 3010, Australia

[2] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Exercise Biomed & Hlth Sci, Perth, WA, Australia

[3] CSIRO Mol & Hlth Technol & P Hlth Flagship, Parkville, Vic, Australia

[4] Hollywood Private Hosp, Sir James McCusker Alzheimers Dis Res Unit, Nedlands, WA, Australia

[5] Univ Western Australia, Sch Psychiat & Clin Neurosci, Crawley, WA, Australia

来源：

FEMS YEAST RESEARCH | 2010年 / 10卷 / 08期

基金：

欧盟地平线“2020”;

关键词：

Alzheimer's disease; amyloid A beta; tau phosphorylation; toxic protein oligomerization; neurotoxicity; AMYLOID-BETA PEPTIDE; C-TERMINAL FRAGMENT; PRECURSOR PROTEIN; GAMMA-SECRETASE; COGNITIVE IMPAIRMENT; OXIDATIVE DAMAGE; APOLIPOPROTEIN-E; TAU-PROTEIN; BRAIN; IDENTIFICATION;

D O I：

10.1111/j.1567-1364.2010.00658.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized.

引用

页码：961 / 969

页数：9

共 84 条

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